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 Table 1 (continued) Table 1 Polyglutamine (CAG Repeat) Neurodegenerative Diseases Repeat number Location of disease (normal)a Disease Sites of pathology Striatum (medium, spiny) Normal Disease 1134 36121 Protein Huntingtin Huntingtons disease NI (c) NI (n, c) NI (c) NI (c) Spinocerebellar ataxia (SCA), type 1 Cerebellar cortex (Purkinje cells), brain stem 639 4081 1529 3664 1342 6184 Ataxin-1 SCA2 Cerebellum, pontine nucleus, substantia nigra Ataxin-2 SCA3 (Machado Joseph disease) Substantia nigra, globus pallidus, pontine nucleus, cerebellar cortex Db forex rates SCA6 SCA7 Cerebellar and mild brain stem atrophy Photoreceptors and bipolar cells, 418 2130 717 37130 VDCCa1Asubunit Ataxin-7 NI (memb) NI (n) Spinal and bulbar muscular atrophy (SBMA) cerebellar cortex, brain stem Motor neurons, dorsal root ganglia 1134 4062 735 4988 Androgen receptor Atrophin-1 NI (n) NI (n) Dentatorubral- palladoluysian atrophy (DRPLA) Globus pallidus, dentatorubral and subthalamic nuclei a NI, nuclear inclusions; (c), normal cytoplasmic localization; (n), normal nuclear localization; (membr), normal membrane localization.
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