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(If it takes more than two drinks to get high or six drinks to feel drunk, tolerance can be assumed to be present). 25a: © Richard Chao; 3. Comments on article by Tran and collea- gues, 12 rate constants, 50 role of transporters, 213 Drug interactions classifications, 229230 clinical management, 243 epidemiology, 229 mechanisms affecting absorption, 230231 affecting distribution, 231 affecting metabolism enzyme induction, 235237, 236f enzyme inhibition, 234235, 234f overview, 232234, 232t234t interactions involving drug transport proteins affecting renal excretion, 242 organic anion transport polypeptides, 241242 P-glycoprotein, 237241, 237t240t prediction and clinical management genetic variation, 243 in vitro screening methods, 242243 transport mechanisms, 213214 Drug kinetics.
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